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Fabrication of novel vesicles of triptolide for antirheumatoid activity with reduced toxicity in vitro and in vivo [Corrigendum]

Authors Zhang L, Wang TT, Li Q, Huang J, Xu H, Li J, Wang Y, Liang Q

Received 28 February 2019

Accepted for publication 28 February 2019

Published 18 April 2019 Volume 2019:14 Pages 2755—2756

DOI https://doi.org/10.2147/IJN.S207139


Zhang L, Wang TT, Li Q, et al. Int J Nanomedicine. 2016;11:2663–2673.

Following a review of their data post-publication, the authors found errors in the kidney and PPT group image used for Figure 7 on page 2671 and the spleen control and PP group images and liver PP and PPT group images used for Figure 8 on page 2671. For accuracy and experimental integrity these images have been corrected, with no impact to the conclusions of the study. The authors apologize for these errors.
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Zhang L, Wang TT, Li Q, et al. Int J Nanomedicine. 2016;11:2663–2673.

Following a review of their data post-publication, the authors found errors in the kidney and PPT group image used for Figure 7 on page 2671 and the spleen control and PP group images and liver PP and PPT group images used for Figure 8 on page 2671. For accuracy and experimental integrity these images have been corrected, with no impact to the conclusions of the study. The authors apologize for these errors.

Figure 7 HE staining of liver, spleen, and kidney. Notes: Three-month-old C57/B6 mice were treated with PBS, PP, TP, or PPT. The liver, spleen, and kidney tissues of every treatment group were harvested for pathologic examination (magnification ×200). The circled areas show the renal glomerulus and the arrow is showing the hepatic nuclei.Abbreviations: HE, hematoxylin and eosin; PBS, phosphate-buffered saline; PP, l-PAAE-γ-PGA complex; l-PAE, l-phenylalanine ethylester; γ-PGA, poly-γ-glutamic acid; TP, triptolide; PPT, γ-PGA-l-PAE-TP.

Figure 8 TUNEL assay in different tissues. Sections of kidney, spleen, and liver tissues of control, PP, TP, and PPT treatment groups were processed for TUNEL assay in order to detect the apoptosis of kidney, spleen, and liver. Nucleus was stained with DAPI (blue), and the apoptosis was stained with green (magnification ×200). Abbreviations: PP, l-PAE-γ-PGA complex; l-PAE, l-phenylalanine ethylester; γ-PGA, poly-γ-glutamic acid; TP, triptolide; PPT, γ-PGA-l-PAE-TP; TUNEL, terminal-deoxynucleotidyl dUTP transferase nick-end labeling; DAPI, 4′,6-diamidino-2-phenylindole.

The corrected figures:

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