Back to Journals » Pharmacogenomics and Personalized Medicine » Volume 14

Correlations Between TIMD-4 Gene Variants and the Risk and Clinical Features of Rheumatoid Arthritis in a Chinese Population

Authors Yang Z, Liu S, Zhou L, Zhang H, Xu N

Received 23 October 2020

Accepted for publication 11 January 2021

Published 9 February 2021 Volume 2021:14 Pages 221—228

DOI https://doi.org/10.2147/PGPM.S287688

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth


Zhicheng Yang,1,* Shuaikun Liu,2,* Li Zhou,1 Hui Zhang,1 Nanwei Xu1

1Department of Orthopedics, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 2Graduate School, Dalian Medical University, Dalian, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Hui Zhang; Nanwei Xu
The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China
Email zjzh1987@126.com; xunanwei1964@tom.com

Introduction: T-cell immunoglobulin and mucin domain-4 (TIMD-4) are likely to impact autoimmune diseases (e.g., rheumatoid arthritis (RA)). It is hypothesized here that TIMD-4 gene polymorphism is likely to display a correlation with the RA risk.
Methods: For examining the effect exerted by TIMD-4 genetic variant in the RA risk, a case–control study containing 379 RA cases and 432 healthy control groups in Chinese population was performed. This study conducted genotyping with the use of a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ Kit. Blood serum conditions of TIMD-4 in RA cases and matched control groups were measured by enzyme-connected immunosorbent assay (ELISA).
Results: Our results demonstrated that the TIMD-4 rs7700944 polymorphism could increase the RA risk in Chinese population. According to stratification analyzing processes, the TIMD-4 rs7700944 polymorphism displayed the correlation to the elevated RA risk in the females, smokers and cases aged ≥ 55 years. Cross-over analyses also indicated that the combined effect of smoking or drinking and GA genotype of rs7700944 locus contributed to an elevated risk of RA. In addition, the TIMD-4 rs7700944 polymorphism was also related to RA cases with DAS ≥ 3.20, ESR ≥ 25.00 mm/h and positive anti-ccp. Moreover, compared with the control groups, the average expression level of TIMD-4 in the serum of RA cases was apparently increased.
Conclusion: In conclusion, the TIMD-4 rs7700944 polymorphism may increase the sensitivity to RA in Chinese population.

Keywords: TIMD-4, polymorphism, rheumatoid arthritis, Chinese population

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]