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Correlation of variable repeat number in the neck regions of DC-SIGN and DC-SIGNR with susceptibility to nasopharyngeal carcinoma in a Chinese population

Authors Ning S, Yao M, Wu Y, Zhou X, Zhong C, Yan K, Wei Z, Xie Y

Received 2 March 2018

Accepted for publication 9 June 2018

Published 4 September 2018 Volume 2018:10 Pages 3193—3198

DOI https://doi.org/10.2147/CMAR.S167114

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Professor Nakshatri


Sisi Ning,1,* Mengwei Yao,1,* Yuan Wu,1 Xunzhao Zhou,1 Changtao Zhong,1 Kui Yan,1 Zhengbo Wei,2 Ying Xie3,4

1Graduate School of Guangxi Medical University, Nanning, China; 2Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China; 3Life Sciences Institute of Guangxi Medical University, Nanning, China; 4Key Laboratory for High-Incidence Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, China

*These authors contributed equally to this work

Objective: To evaluate the potential association of variations in the number of tandem repeats in the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin-related (DC-SIGNR) neck region with susceptibility to nasopharyngeal carcinoma (NPC).
Methods: Variations in the number of repeats in the genotypes and alleles in the neck region of DC-SIGN/DC-SIGNR were analyzed in 477 unrelated NPC patients and 561 cancer-free controls.
Results: Genotypes and alleles in the DC-SIGN neck region did not differ significantly between NPC patients and controls, but the 9-repeat genotype in the DC-SIGNR neck region was significantly more frequent among patients (OR 1.339, 95% CI 1.018–1.760, P=0.037). The association between this genotype and NPC remained significant after adjusting for sex, age, smoking history, and presence of immunoglobulin against Epstein–Barr virus viral capsid antigen (OR 1.625, 95% CI 1.134–2.329, P=0.0082).
Conclusion: These results suggest that genotypes/alleles in the DC-SIGN neck region are not associated with NPC susceptibility, whereas the 9-repeat variant in the neck region of DC-SIGNR may increase the risk of NPC.

Keywords: nasopharyngeal carcinoma, DC-SIGN, DC-SIGNR, genetic polymorphism, neck region repeat variation

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