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Correlation between thromboelastography and traditional coagulation test parameters in hospitalized dogs

Authors Rubanick JV, Pashmakova MB, Bishop MA, Barr JW

Received 15 September 2016

Accepted for publication 14 December 2016

Published 8 February 2017 Volume 2017:8 Pages 21—26


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Young Lyoo

Jean V Rubanick, Medora B Pashmakova, Micah A Bishop, James W Barr

Department of Veterinary Small Animal Clinical Sciences, Texas A&M University, College Station, TX, USA

Abstract: A hospital-based, prospective cross-sectional study was used to compare kaolin-activated thromboelastography (TEG) parameters with traditional coagulation tests in 29 hospitalized dogs. Cases were included if the attending clinician requested coagulation testing. Blood was obtained from each dog and coagulation (prothrombin time, partial thromboplastin time, antithrombin activity, d-dimer concentration, and fibrinogen concentration) and TEG analyses were performed. Hematocrit (Hct) was also measured. Traditional coagulation results were evaluated for correlation with those from kaolin-activated TEG. Spearman’s correlation was used to calculate correlation coefficients. Fibrinogen was positively correlated with maximum amplitude (Pearson r=0.72, P<0.001) and global clot strength (Pearson r=0.72, P<0.001). There was no correlation between any of the remaining coagulation variables, TEG parameters, or Hct. Results of kaolin-activated TEG and traditional coagulation tests are not interchangeable means of monitoring coagulation derangements in this intensive care unit patient population. Determination of a true outcome measure is necessary to establish TEG’s clinical relevance to veterinary medicine.

Keywords: TEG, thromboelastography, coagulation, hemostasis

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