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Correlation between optic nerve head structural parameters and glaucomatous visual field indices

Authors Mizumoto K, Gosho M, Zako M

Received 15 February 2014

Accepted for publication 12 May 2014

Published 25 June 2014 Volume 2014:8 Pages 1203—1208


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Kyoichi Mizumoto,1 Masahiko Gosho,2 Masahiro Zako1

1Department of Ophthalmology, Aichi Medical University, Nagakute, Aichi, Japan; 2Advanced Medical Research Center, Aichi Medical University, Nagakute, Aichi, Japan

Abstract: We examined associations between optic nerve head structural parameters and glaucomatous visual field indices. The study population included patients with glaucomatous optic neuropathy who were evaluated at Aichi Medical University, Nagakute, Aichi, Japan, from October 2010 to January 2011. A total of 57 eyes from 33 patients were assessed. We measured visual field using a Humphrey field analyzer, peripapillary retinal nerve fiber layer thickness (RNFL-T), and Bruch’s membrane opening-minimum rim width (BMO-MRW) using spectral domain optical coherence tomography, and rim area with referring three-dimensional photography. Spearman’s rank correlation coefficients were calculated between the threshold of visual sensitivity or total deviation of visual field and the following five optic nerve head structural parameters: RNFL-T length, BMO-MRW length, rim area, and calculated RNFL-T and BMO-MRW volumes (each length multiplied by rim area). The Akaike information criterion was calculated to determine which structural parameter was the best predictor of each visual field index. Threshold of visual sensitivity had correlation coefficients of 0.23 with global sector of RNFL-T, 0.32 with BMO-MRW, 0.14 with rim area, 0.21 with RNFL-T volume, and 0.26 with BMO-MRW volume. The correlation coefficients for each parameter with total deviation of visual field were 0.22, 0.33, 0.28, 0.36, and 0.37, respectively. The Akaike information criterion of BMO-MRW showed the smallest values in analyses of both threshold of visual sensitivity and total deviation. The present results show that RNFL-T volume and BMO-MRW volume were more strongly correlated with total deviation than BMO-MRW, but BMO-MRW appeared to be the best predictor of the two glaucomatous visual field indices.

Keywords: Bruch’s membrane opening-minimum rim width, glaucoma, retinal nerve fiber layer thickness, rim area, spectral domain optical coherence tomography, visual field

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