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Correlation between myocardial enzyme serum levels and markers of inflammation with severity of coronary artery disease and Gensini score: A hospital-based, prospective study in Greek patients

Authors Peppes V, Rammos G, Manios E, Koroboki E, Rokas S, Zakopoulos N

Published 5 December 2008 Volume 2008:3(4) Pages 699—710


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Vasileios Peppes, George Rammos, Efstathios Manios, Eleni Koroboki, Stylianos Rokas, Nikolaos Zakopoulos

Department of Clinical Therapeutics, Alexandra Hospital, University of Athens School of Medicine, Athens, Greece

Background: Our objective was to associate serum levels of myocardial enzymes and inflammatory biomarkers with severity of coronary artery disease (CAD).

Patients and methods: 123 patients participated in our study, including 65 cases of acute myocardial infarction (MI), 27 cases of newly diagnosed CAD – without MI – and 31 controls. In all subjects, myocardial serum enzyme levels (creatine phosphokinase, aspartate aminotransferase, lactate dehydrogenase) and inflammatory indices (C-reactive protein, fibrinogen, white blood cells, and erythrocyte sedimentation rate) were measured. Patients were all submitted to coronary angiography and CAD severity was evaluated by Gensini score.

Results: Significant differences concerning enzyme serum levels and inflammatory indices were found to exist between the three study groups, being highest among patients with acute MI (p < 0.001). A significant  association was demonstrated between Gensini score and serum enzyme levels as well as inflammatory biomarkers.

Conclusions: Our findings suggest that serum levels of myocardial enzymes and inflammatory indices correlate with CAD severity in Greek patients.

Keywords: myocardial enzymes, inflammation, coronary angiography, coronary artery disease

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