Back to Browse Journals » Clinical Ophthalmology » Volume 4
Correlation between morphology of optic disc determined by Heidelberg Retina Tomograph II and visual function in eyes with open-angle glaucoma
Authors Kazuko Omodaka, Toru Nakazawa, Takaaki Otomo, et al
Published 14 July 2010 Volume 2010:4 Pages 765—772
DOI https://doi.org/10.2147/OPTH.S9741
Review by Single-blind
Peer reviewer comments 2
Kazuko Omodaka, Toru Nakazawa, Takaaki Otomo, Masahiko Nakamura, Nobuo Fuse, Kohji Nishida
Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan
Patients and Methods: One hundred and three eyes of 76 patients with OAG were studied. The baseline optic disc morphology was used to classify the eyes into four types: focal ischemic type (FI), myopic glaucomatous type (MY), senile sclerotic type (SS), and generalized enlargement type (GE). The morphological parameters of the disc were determined by the Heidelberg Retina Tomograph II (HRT-II) and the visual function by the mean deviation (MD) of the Humphrey field analyzer.
Results: Fourteen eyes were classified as the FI type; 52 as the MY type; 17 as the SS type; and 20 as the GE type. The highest correlation coefficients of HRT-II parameters to the MDs was the cup/disc area ratio (r = -0.27) for all groups, the vertical cup/disc ratio (r = -0.42) in the MY group, the maximum cup depth (r = 0.49) in the SS group, and the cup area (r = -0.70) in the GE group. However, none of the parameters was correlated in the FI group.
Conclusions: The correlation between the HRT-II parameters and MDs was different for the four disc types. These findings suggest that a classification of optic disc morphology had a benefit for interpreting the measured values of HRT-II.
Keywords: open angle glaucoma, optic disc morphology, classification, visual function
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.
By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
Other articles by this author:
Significant correlations between optic nerve head microcirculation and visual field defects and nerve fiber layer loss in glaucoma patients with myopic glaucomatous disk
Yokoyama Y, Aizawa N, Chiba N, Omodaka K, Nakamura M, Otomo T, Yokokura S, Fuse N, Nakazawa T
Clinical Ophthalmology 2011, 5:1721-1727
Published Date: 7 December 2011
Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
Chiba N, Omodaka K, Yokoyama Y, Aizawa N, Tsuda S, Yasuda M, Otomo T, Yokokura S, Fuse N, Nakazawa T
Clinical Ophthalmology 2011, 5:1549-1556
Published Date: 28 October 2011
Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
Aizawa N, Yokoyama Y, Chiba N, Omodaka K, Yasuda M, Otomo T, Nakamura M, Fuse N, Nakazawa T
Clinical Ophthalmology 2011, 5:1171-1176
Published Date: 19 August 2011
Correlation between peripapillary macular fiber layer thickness and visual acuity in patients with open-angle glaucoma
Kazuko Omodaka, Toru Nakazawa, Yu Yokoyama, et al
Clinical Ophthalmology 2010, 4:629-635
Published Date: 30 June 2010
Readers of this article also read:
Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus
Jeong HR, An SSA
Clinical Interventions in Aging 2015, 10:1873-1879
Published Date: 19 November 2015
Mutations in presenilin 2 and its implications in Alzheimer’s disease and other dementia-associated disorders
Cai Y, An SSA, Kim SY
Clinical Interventions in Aging 2015, 10:1163-1172
Published Date: 14 July 2015
Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles
Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM
International Journal of Nanomedicine 2014, 9:1883-1889
Published Date: 16 April 2014
Single- and multiple-dose pharmacokinetics, pharmacodynamics, and safety of apixaban in healthy Chinese subjects [Corrigendum]
Cui Y, Song Y, Wang J, Yu Z, Schuster A, Barrett YC, Frost C
Clinical Pharmacology: Advances and Applications 2014, 6:61-62
Published Date: 27 March 2014
Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon
Ashwanikumar N, Kumar NA, Nair SA, Kumar GS
International Journal of Nanomedicine 2012, 7:5769-5779
Published Date: 15 November 2012
A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone
Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W
International Journal of Nanomedicine 2012, 7:5719-5724
Published Date: 12 November 2012
Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy
Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS
International Journal of Nanomedicine 2012, 7:4077-4088
Published Date: 27 July 2012
Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs
Rao S, Song Y, Peddie F, Evans AM
International Journal of Nanomedicine 2011, 6:1245-1251
Published Date: 20 June 2011
Crystallization after intravitreal ganciclovir injection
Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant
Clinical Ophthalmology 2010, 4:709-711
Published Date: 14 July 2010
Characterization of complexation of poly (N-isopropylacrylamide-co-2-(dimethylamino) ethyl methacrylate) thermoresponsive cationic nanogels with salmon sperm DNA
Jim Moselhy, Tasnim Vira, Fei-Fei Liu, et al
International Journal of Nanomedicine 2009, 4:153-164
Published Date: 24 August 2009
