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Control of Spinal Anesthesia-Induced Hypotension in Adults

Authors Ferré F, Martin C, Bosch L, Kurrek M, Lairez O, Minville V

Received 2 December 2019

Accepted for publication 27 March 2020

Published 3 June 2020 Volume 2020:13 Pages 39—46

DOI https://doi.org/10.2147/LRA.S240753

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Stefan Wirz


Fabrice Ferré,1 Charlotte Martin,1 Laetitia Bosch,1 Matt Kurrek,1,2 Olivier Lairez,3,4 Vincent Minville1

1Department of Anesthesia and Intensive Care Medicine, CHU Purpan, Toulouse, France; 2Department of Anesthesia, University of Toronto, Toronto, ON M5S 3E2, Canada; 3Department of Nuclear Medicine, Toulouse University Hospital, Toulouse Cedex 9 31059, France; 4Department of Cardiology, Toulouse University Hospital, Toulouse Cedex 9 31059, France

Correspondence: Vincent Minville
Department of Anesthesia and Intensive Care Medicine, Purpan University Hospital, Hôpital Purpan, Place du Dr Baylac, TSA 40  031, Toulouse Cedex 9 31059, France
Email minville.v@chu-toulouse.fr

Abstract: Spinal anesthesia-induced hypotension (SAIH) occurs frequently, particularly in the elderly and in patients undergoing caesarean section. SAIH is caused by arterial and venous vasodilatation resulting from the sympathetic block along with a paradoxical activation of cardioinhibitory receptors. Bradycardia after spinal anesthesia (SA) must always be treated as a warning sign of an important hemodynamic compromise. Fluid preloading (before initiation of the SA) with colloids such as hydroxyethyl starch (HES) effectively reduces the incidence and severity of arterial hypotension, whereas crystalloid preloading is not indicated. Co-loading with crystalloid or colloid is as equally effective to HES preloading, provided that the speed of administration is adequate (ie, bolus over 5 to 10 minutes). Ephedrine has traditionally been considered the vasoconstrictor of choice, especially for use during SAIH associated with bradycardia. Phenylephrine, a α1 adrenergic receptor agonist, is increasingly used to treat SAIH and its prophylactic administration (ie, immediately after intrathecal injection of local anesthetics) has been shown to decrease the incidence of arterial hypotension. The role of norepinephrine as a possible alternative to phenylephrine seems promising. Other drugs, such as serotonin receptor antagonists (ondansetron), have been shown to limit the blood pressure drop after SA by inhibiting the Bezold–Jarisch reflex (BJR), but further studies are needed before their widespread use can be recommended.

Keywords: spinal anesthesia, arterial hypotension, vasopressor, phenylephrine, ondansetron

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