Back to Journals » Clinical Interventions in Aging » Volume 14

Continuous positive airway pressure improves nocturnal polyuria in ischemic stroke patients with obstructive sleep apnea

Authors Yu CC, Huang CY, Kuo WK, Chen CY

Received 5 November 2018

Accepted for publication 3 January 2019

Published 31 January 2019 Volume 2019:14 Pages 241—247


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Zhi-Ying Wu

Chung-Chieh Yu,1–3 Chih-Yu Huang,1–3 Wei-Ke Kuo,1–3 Chung-Yao Chen2,4

1Division of Pulmonary Critical Care and Sleep Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; 2Department of Medicine, College of Medicine, Chang Gung University, Taoyuan City, Taiwan; 3Department of Respiratory Therapy, Chang Gung Memorial Hospital, Keelung, Taiwan; 4Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, Taiwan

Objectives: To assess the effect of continuous positive airway pressure (CPAP) on nocturia in ischemic stroke patients with obstructive sleep apnea (OSA).
Methods: This was a prospective and non-randomized controlled study in which ischemic stroke patients with OSA being treated in a rehabilitation ward were enrolled. The participants who tolerated CPAP were classified as the CPAP group, while those who refused or could not tolerate CPAP were classified as the control group. The percentage change of nocturia before and after 2 weeks of CPAP therapy between the two groups were compared.
Results: A total of 44 participants were enrolled in and 35 participants (mean age=59.8±11.7 years old; mean apnea hypopnea index=42.9±16.7/h) completed the study (control group: 14, CPAP group: 21). Overall, 69% of the participants had nocturnal polyuria and 69% of them had more than one nocturia episode per night. The baseline and initial nocturia characteristics did not differ significantly between the two groups. As compared to the control group, CPAP therapy significantly decreased the nocturnal polyuria index (mean percentage change: 9% vs -21% (P=0.005)) and nocturnal urine output (mean percentage change: 6% vs -26% (P=0.04)), but not the nocturia episodes or 24-hours total urine output.
Conclusion: Nocturia due to nocturnal polyuria is very common in post-stroke patients with OSA. Treating OSA by CPAP significantly reduces nocturnal polyuria, but not nocturia frequency, in ischemic stroke patients.

Keywords: nocturia, nocturnal polyuria index, nocturnal urine output, multiple comorbidities

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]