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Considering renal risk while managing cancer

Authors Shahinian VB, Bahl A, Niepel D, Lorusso V

Received 27 October 2016

Accepted for publication 20 February 2017

Published 16 May 2017 Volume 2017:9 Pages 167—178

DOI https://doi.org/10.2147/CMAR.S125864

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 4

Editor who approved publication: Dr Kenan Onel


Vahakn B Shahinian,1 Amit Bahl,2 Daniela Niepel,3 Vito Lorusso4

1Department of Internal Medicine, Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, MI, USA; 2Bristol Haematology and Oncology Centre, University Hospitals Bristol, Bristol, UK; 3Medical Development, Amgen (Europe) GmbH, Vienna, Austria; 4Medical Oncology Unit, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Bari, Italy

Abstract: Renal function is an important consideration in the management of patients with advanced cancer. There is a reciprocal relationship between cancer and the kidney: chronic ­kidney disease can increase the risk of developing cancer, and patients with cancer often experience renal impairment owing to age, disease-related factors and nephrotoxic treatments. As therapies for cancer continue to improve, patients are living longer with their disease, potentially extending the period over which they are susceptible to long-term complications. Furthermore, secondary symptoms, such as bone metastases or infections, may arise that will require treatment. Certain treatments, including chemotherapy, antibiotics and some bone-targeted agents, are nephrotoxic and may require dose modifications or interruptions to prevent renal injury. Nephrologists should play a key role in the identification and management of renal impairment in patients with cancer. Furthermore, they may be able to provide advice on protecting the kidneys in instances where nephrotoxic agents require dose reductions or interruptions, and when novel therapies or combinations are used. Collaboration between oncologists and nephrologists is important to optimal patient management. This article reviews the relationship between cancer and kidney disease and examines the treatments that may impact kidney function. Considerations for monitoring renal function are also discussed.

Keywords: advanced cancer, cancer management, elderly, kidney disease, nephrotoxicity, renal function

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