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Congenital anomaly of the inferior vena cava and factor V Leiden mutation predisposing to deep vein thrombosis

Authors Lamparello BM, Erickson CR, Kulthia A, Virparia V, Thet Z

Received 16 April 2014

Accepted for publication 6 June 2014

Published 4 November 2014 Volume 2014:10 Pages 609—613

DOI https://doi.org/10.2147/VHRM.S66283

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Video abstract presented by Brooke M Lamparello.

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Brooke M Lamparello,1,* Cameron R Erickson,2,* Arun Kulthia,3 Vasudev Virparia,3 Zeyar Thet3

1St George’s University, Grenada, West Indies; 2Northeast Ohio Medical University, Rootstown, OH, USA; 3Department of Medicine, Coney Island Hospital, Brooklyn, NY, USA

*These authors contributed equally to this work


Abstract: A previously healthy 21-year-old man presented with back pain, bilateral extremity pain, and right lower extremity weakness, paresthesias, and swelling. Sonographic examination revealed diffuse deep vein thrombosis (DVT) in the femoral and popliteal venous system. CT imaging revealed hypoplasia of the hepatic inferior vena cava (IVC) segment with formation of multiple varices and collateral veins around the kidneys. Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT. The rare, often overlooked occurrence of attenuated IVC, especially in the setting of hypercoagulable state, can predispose patients to significant thrombosis.

Keywords: inferior vena cava (IVC), deep vein thrombosis (DVT), lower extremities, thrombophilic, venography

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