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Conestat alfa for the treatment of angioedema attacks

Authors Davis, Bernstein J

Published 1 July 2011 Volume 2011:7 Pages 265—273

DOI https://doi.org/10.2147/TCRM.S15544

Review by Single-blind

Peer reviewer comments 3


Benjamin Davis, Jonathan A Bernstein
University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section, Cincinnati, OH, USA

Abstract: Recently, multiple C1 inhibitor (C1-INH) replacement products have been approved for the treatment of hereditary angioedema (HAE). This review summarizes HAE and its current treatment modalities and focuses on findings from bench to bedside trials of a new C1-INH replacement, conestat alfa. Conestat alfa is unique among the other C1-INH replacement products because it is produced from transgenic rabbits rather than derived from human plasma donors, which can potentially allow an unlimited source of drug without any concern of infectious transmission. The clinical trial data generated to date indicate that conestat alfa is safe and effective for the treatment of acute HAE attacks.

Keywords: androgens, adverse events, patients, HAE attacks
 

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