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Complications and management of coagulation disorders in leukemia patients

Authors Lad DP, Jain A, Varma S

Received 6 June 2017

Accepted for publication 26 August 2017

Published 18 September 2017 Volume 2017:7 Pages 61—72

DOI https://doi.org/10.2147/BLCTT.S125121

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor David Dingli


Deepesh Lad, Arihant Jain, Subhash Varma

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Abstract: Patients with leukemia are predisposed to various coagulation abnormalities. Thrombosis and bleeding continue to be a major cause of morbidity and mortality in leukemias. The pathophysiology of these disorders is unique, and not only the disease but also the treatment and other factors play a role. There has been an increase in the understanding of these disorders in leukemias. However, it is still difficult to predict when and which patients will have these complications. The evidence for the management of coagulation abnormalities in leukemias is still evolving and not as established as in solid malignancies. The management of these disorders is complex, and making clinical decisions is often challenging. In the era of specialization, where there are different hematologists looking after benign- and malignant-hematology patients, opinions of thrombosis experts are often sought by leukemia specialists. This review aims to bridge the gap in the knowledge of these disorders between these specialists.

Keywords: leukemia, coagulation, thrombosis, bleeding

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