Back to Journals » Clinical Epidemiology » Volume 4 » Supplement 2 Cancer staging

Completeness of prostate cancer staging in the Danish Cancer Registry, 2004–2009

Authors Nguyen-Nielsen M, Froeslev T, Friis S, Borre M, Harving, Søgaard M

Received 21 March 2012

Accepted for publication 4 May 2012

Published 17 August 2012 Volume 2012:4(Supplement 2 Cancer staging) Pages 17—23

DOI https://doi.org/10.2147/CLEP.S32004

Review by Single-blind

Peer reviewer comments 2


Mary Nguyen-Nielsen,1 Trine Frøslev,1 Søren Friis,2 Michael Borre,3 Niels Harving,4 Mette Søgaard1,5

1
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, 2Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, 3Department of Urology, Aarhus University Hospital at Skejby, Aarhus, 4Department of Urology, Aalborg Hospital, Aarhus University Hospital, Aalborg, 5Department of Clinical Microbiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

Objective: To investigate the completeness of TNM (Tumor-Node-Metastasis) staging for prostate cancer (PC) in the Danish Cancer Registry (DCR).
Methods: We identified 20,184 men registered with first-time PC in the DCR between 2004 and 2009. These patients were linked to the Danish National Patient Register to obtain data on comorbidity according to the Charlson Comorbidity Index (CCI). We calculated the completeness and corresponding 95% confidence intervals (CI) of TNM staging overall and by the individual components. We also defined a clinically-based algorithm classifying PC into four stage categories: localized, regional, distant, and unknown.
Results: The overall completeness of TNM staging was 34.2% (95% CI: 0.34–0.35). TNM completeness improved gradually over time reaching 41.2% in 2009. TNM completeness decreased substantially with age from 75.0% among patients 0–39 years to 11.3% among patients 80 years or older. Similarly, completeness decreased with increasing comorbidity level from 37.6% among patients with low CCI to 20.3% among those with high CCI. When classifying T1 cancer as a complete registration regardless of missing N or M stage, the overall TNM completeness increased to 48.7% (95% CI: 0.48–0.49). According to the clinically-based staging algorithm, 70.5% of PC cases could be categorized into a definite clinical stage.
Conclusion: One-third of PC patients had a complete registration of all TNM components in the DCR. Although TNM completeness improved over time, older age and high comorbidity were consistently associated with missing TNM staging. Research and monitoring based on cancer registries such as the DCR should account for missing TNM staging. Failing to do so could otherwise lead to biased results of stage-specific analyses.

Keywords: prostate cancer, neoplasm staging, TNM

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]