Completeness of breast cancer staging in the Danish Cancer Registry, 2004–2009
Authors Ording A, Nielsson MS, Froeslev T, Friis S, Garne, Søgaard M
Received 7 March 2012
Accepted for publication 12 April 2012
Published 17 August 2012 Volume 2012:4(Supplement 2 Cancer staging) Pages 11—16
Review by Single anonymous peer review
Peer reviewer comments 3
Anne Gulbech Ording,1 Malene Schou Nielsson,1 Trine Frøslev,1 Søren Friis,2 Jens Peter Garne,3 Mette Søgaard1,4
1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, 2Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, 3Department of Breast Surgery, 4Department of Clinical Microbiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
Background: The purpose of this study was to investigate the completeness of TNM (Tumor, Node, Metastasis) staging for breast cancer in the Danish Cancer Registry.
Methods: We identified 26,488 patients with a first diagnosis of breast cancer between 2004 and 2009 from the Danish Cancer Registry. We obtained information on comorbidity through the Danish National Patient Registry. We estimated the completeness of TNM registration in the Danish Cancer Registry and stratified the analysis by gender, age, year of cancer diagnosis, and comorbidity. We designed an algorithm categorizing breast cancer into localized, regional, distant, or unknown stage based on TNM codes.
Results: The overall completeness of TNM registration was 85.4%. The completeness varied little by gender and study year, but decreased from 91.3% in patients aged 0–39 years to 57.0% in patients aged 80 years or more, and from 87.9% among patients with a low level of comorbidity to 69.7% among patients with a high level of comorbidity.
Conclusion: The completeness of the TNM registration varied substantially by age and level of comorbidity. Thus, depending on the outcome under study, stage-specific analyses may yield biased results. The completeness of TNM should be considered in study designs using TNM information.
Keywords: neoplasm staging, breast neoplasms, registries
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]