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Comparison of prophylactic higher fluence corneal cross-linking to control, in myopic LASIK, one year results

Authors Kanellopoulos AJ, Asimellis G, Karabatsas C

Received 24 May 2014

Accepted for publication 26 June 2014

Published 27 November 2014 Volume 2014:8 Pages 2373—2381

DOI https://doi.org/10.2147/OPTH.S68372

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Anastasios John Kanellopoulos,1,2 George Asimellis,1 Costas Karabatsas1

1LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USA

Purpose: To compare 1-year results: safety, efficacy, refractive and keratometric stability, of femtosecond myopic laser-assisted in situ keratomileusis (LASIK) with and without concurrent prophylactic high-fluence cross-linking (CXL) (LASIK-CXL).
Methods: We studied a total of 155 consecutive eyes planned for LASIK myopic correction. Group A represented 73 eyes that were treated additionally with concurrent prophylactic high-fluence CXL; group B included 82 eyes subjected to the stand-alone LASIK procedure. The following parameters were evaluated preoperatively and up to 1-year postoperatively: manifest refractive spherical equivalent (MRSE), refractive astigmatism, visual acuity, corneal keratometry, and endothelial cell counts. We plotted keratometry measurements pre-operatively and its change in the early, interim and later post-operative time for the two groups, as a means of keratometric stability comparison.
Results: Group A (LASIK-CXL) had an average postoperative MRSE of -0.23, -0.19, and -0.19 D for the 3-, 6-, and 12-month period, respectively, compared to -6.58±1.98 D preoperatively. Flat keratometry was 37.69, 37.66, and 37.67 D, compared to 43.94 D preoperatively, and steep keratometry was 38.35, 38.36, and 38.37 D, compared to 45.17 D preoperatively. The predictability of Manifest Refraction Spherical Equivalent (MRSE) correction showed a correlation coefficient of 0.979. Group B (stand-alone LASIK) had an average postoperative MRSE of -0.23, -0.20, and -0.27 D for the 3-, 6-, and 12-month period, respectively, compared with -5.14±2.34 D preoperatively. Flat keratometry was 37.65, 37.89, and 38.02 D, compared with 43.15 D preoperatively, and steep keratometry was 38.32, 38.57, and 38.66 D, compared with 44.07 D preoperatively. The predictability of MRSE correction showed a correlation coefficient of 0.970. The keratometric stability plots were stable for the LASIK CXL group and slightly regressing in the standard LASIK group, a novel stability evaluation metric that may escape routine acuity and refraction measurements.
Conclusion: Application of prophylactic CXL concurrently with myopic LASIK surgery appears to contribute to improved refractive and keratometric stability compared to standard LASIK. The procedure appears safe and provides a new potential for LASIK correction.

Keywords: myopic LASIK regression, femtosecond myopic LASIK, LASIK-CXL, LASIK-Xtra, high myopia, accelerated high-fluence collagen cross-linking

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