Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Comparison of laboratory- and field-based exercise tests for COPD: a systematic review

Authors Fotheringham I, Meakin G, Punekar YS, Riley JH, Cockle SM, Singh SJ

Received 2 July 2014

Accepted for publication 10 October 2014

Published 19 March 2015 Volume 2015:10(1) Pages 625—643

DOI https://doi.org/10.2147/COPD.S70518

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Editor who approved publication: Dr Richard Russell

Iain Fotheringham,1 Georgina Meakin,1 Yogesh Suresh Punekar,2 John H Riley,2 Sarah M Cockle,2 Sally J Singh3

1Value Demonstration Practice, Oxford PharmaGenesis, Oxford, 2GlaxoSmithKline, Uxbridge, 3Department of Respiratory Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK

Abstract: Exercise tests are often used to evaluate the functional status of patients with COPD. However, to the best of our knowledge, a comprehensive systematic comparison of these tests has not been performed. We systematically reviewed studies reporting the repeatability and/or reproducibility of these tests, and studies comparing their sensitivity to therapeutic intervention. A systematic review identified primary manuscripts in English reporting relevant data on the following exercise tests: 6-minute walk test (6MWT) and 12-minute walk test, incremental and endurance shuttle walk tests (ISWT and ESWT, respectively), incremental and endurance cycle ergometer tests, and incremental and endurance treadmill tests. We identified 71 relevant studies. Good repeatability (for the 6MWT and ESWT) and reproducibility (for the 6MWT, 12-minute walk test, ISWT, ESWT, and incremental cycle ergometer test) were reported by most studies assessing these tests, providing patients were familiarized with them beforehand. The 6MWT, ISWT, and particularly the ESWT were reported to be sensitive to therapeutic intervention. Protocol variations (eg, track layout or supplemental oxygen use) affected performance significantly in several studies. This review shows that while the validity of several tests has been established, for others further study is required. Future work will assess the link between these tests, physiological mechanisms, and patient-reported measures.

Keywords: 6MWT, 12MWT, COPD, walk test, repeatability, reproducibility, shuttle walk test, cycle ergometer test

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Long-term evaluation of home-based pulmonary rehabilitation in patients with COPD

Grosbois JM, Gicquello A, Langlois C, Le Rouzic O, Bart F, Wallaert B, Chenivesse C

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:2037-2044

Published Date: 25 September 2015

COPD and its association with smoking in the Mainland China: a cross-sectional analysis of 0.5 million men and women from ten diverse areas

Kurmi OP, Li L, Wang J, Millwood IY, Chen J, Collins R, Guo Y, Bian Z, Li J, Chen B, Xie K, Jia W, Gao Y, Peto R, Chen Z

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:655-665

Published Date: 20 March 2015

Oral and pharyngeal bolus transit in patients with chronic obstructive pulmonary disease

Cassiani RA, Santos CM, Baddini-Martinez J, Dantas RO

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:489-496

Published Date: 5 March 2015