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Comparison of commercial fibrin sealants in facelift surgery: a prospective study

Authors Botti G, Pascali M, Botti C, Bodog F, Gentile P, Cervelli V

Received 15 March 2013

Accepted for publication 22 August 2013

Published 7 November 2013 Volume 2013:6 Pages 273—280


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Giovanni Botti,1 Michele Pascali,2 Chiara Botti,1 Florian Bodog,3 Pietro Gentile,2 Valerio Cervelli2

1Villa Bella Clinic, Salò, 2Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Italy; 3University of Oradea, Oradea, Romania

Background: The aim of this study was to compare the effects of two types of fibrin glue in patients undergoing facelift surgery.
Methods: A prospective, controlled "right-left side" study was carried out in 20 patients. The two fibrin sealants used were Quixil® and Tissucol®. The two sealants were used at the same time, ie, one on one side of the face and the other on the contralateral side. Comparisons were made with regard to rates of hematoma and seroma, degree of induration, edema, ecchymosis, pain levels, and patient satisfaction.
Results: The results were almost equivalent. The only exception was a significant (40 mL) hematoma in a patient treated with Quixil. Bleeding was most likely due to a sudden rise in blood pressure during the immediate postoperative period. However, it must be emphasized that, while Tissucol actually seals the undermined area, thus virtually eliminating the dead space, Quixil acts differently, in that its effectiveness in preventing hematoma is linked mainly to its hemostatic effect.
Conclusion: The two fibrin sealants used were nearly identical with regard to patient safety and quality of the result. Nevertheless, it is noted that, while Tissucol has both hemostatic and "gluing" effects, Quixil is mainly effective in securing hemostasis.

Keywords: facelift surgery, rhytidectomy, fibrin sealants, hematoma

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