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Comparison of CHOP vs CHOPE for treatment of peripheral T-cell lymphoma: a meta-analysis

Authors Deng S, Lin S, Shen J, Zeng Y

Received 5 October 2018

Accepted for publication 19 December 2018

Published 28 March 2019 Volume 2019:12 Pages 2335—2342

DOI https://doi.org/10.2147/OTT.S189825

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 2

Editor who approved publication: Dr Federico Perche


Shu Deng,1 Shenyun Lin,1 Jianping Shen,1 Yuqing Zeng2

1Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310006, China; 2Department of Orthopedics, TongDe Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China

Objective: To compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP plus etoposide (CHOPE) with regard to outcomes including efficacy and safety for patients with peripheral T-cell lymphoma (PTCL).
Methods: Relevant literature was searched using PubMed, Embase, Wanfang, and CNKI for eligible trials comparing CHOP with CHOPE for treatment of PTCL. The following outcomes of PTCL patients were considered: complete response (CR), partial response (PR), overall response rate (ORR), and adverse events (AEs; grade ≥3). Risk ratios (RRs) were appropriately derived from fixed-effects or random-effects models.
Results: A total of five prospective or retrospective articles with 1,560 patients were elected for the meta-analysis. There were no significant differences in CR (RR =1.11, 95% CI: 0.73–1.67, P=0.632), PR (RR =1.40, 95% CI: 0.52–3.76, P=0.504), and ORR (RR =1.25, 95% CI: 0.93–1.69, P=0.146) between the CHOP and CHOPE groups. However, AEs including anemia (RR =1.69, 95% CI: 1.33–2.16, P<0.001) and thrombocytopenia (RR =1.43, 95% CI: 1.15–1.77, P=0.001) were significantly increased in CHOPE group compared to that in CHOP group.
Conclusion: Meta-analysis suggested that there were no differences in therapeutic effect for patients with PTCL between CHOP and CHOPE groups with regards to CR, PR, and ORR, whereas the CHOPE group had significantly increased AEs (anemia and thrombocytopenia) compared to CHOP group.

Keywords: peripheral T-cell lymphoma, complete response, partial response, overall response rate, adverse events


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