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Comparison between the EX-PRESS P-50 implant and trabeculectomy in patients with open-angle glaucoma

Authors Mendoza Mendieta ME, López-Venegas A, Valdes-Casas G

Received 21 August 2015

Accepted for publication 31 October 2015

Published 4 February 2016 Volume 2016:10 Pages 269—276


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

María Elena Mendoza-Mendieta,1 Ana Paola López-Venegas,2 Gerardo Valdés-Casas3

1Department of Anterior Segment, Dr Luis Sánchez Bulnes Hospital, Association to Prevent Blindness, Mexico City, Mexico; 2Institute of Ophthalmology, Conde de Valenciana, Mexico City, Mexico; 3Department of General Ophthalmology, Institute of Ophthalmology, Conde de Valenciana, Mexico City, Mexico

Purpose: To evaluate the EX-PRESS P-50 implant compared to standard trabeculectomy (TBC).
Methods: Single-center prospective randomized study; 20 eyes of 20 patients were treated with the EX-PRESS P-50 implant, and 20 eyes of 20 patients with TBC, over a 19-month period. Records of all patients were reviewed and compared. Success was defined as intraocular pressure (IOP) <21 and >5 mmHg or a decrease of 30% of IOP. Failure was defined as >21 mmHg or decline in visual acuity. Statistical analysis was made with Student’s t-test and χ2 test analyzed with SPSS version 13.0.
Results: The average follow-up was 8.6 months (±4.9 months) for the EX-PRESS P-50 group and 9.6 months (±5.3 months) for the TBC group. The postoperative visual acuity and IOP were not significantly different. We report more complications in the EX-PRESS P-50 group. At 3, 6, and 12 months follow-up, the control group was found to be free of complications, whereas multiple complications were observed in the EX-PRESS P-50 group at 3 and 6 months follow-up. We found no differences in either group with respect to success.
Conclusion: Both procedures are equally effective for the treatment of glaucoma, with 80% success in the EX-PRESS P-50 group and 72.7% in the control group.

Keywords: glaucoma, IOP, EX-PRESS, trabeculectomy

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