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Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women

Authors Lustosa LP, Batista PP, Pereira DS, Pereira LS, Scianni A, Ribeiro-Samora GA

Received 13 April 2017

Accepted for publication 27 June 2017

Published 2 August 2017 Volume 2017:12 Pages 1183—1191

DOI https://doi.org/10.2147/CIA.S139579

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Lygia Paccini Lustosa,1 Patrícia Parreira Batista,1 Daniele Sirineu Pereira,2 Leani Souza Máximo Pereira,1 Aline Scianni,1 Giane Amorim Ribeiro-Samora1

1Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, 2Physical Therapy Department, Universidade Federal de Alfenas, Alfenas, Brazil

Background: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function.
Objective: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil.
Material and methods: The diagnosis of sarcopenia included measurements of body composition (by densitometry with dual energy source of X-ray), handgrip strength (by Jamar® dynamometer), and the usual gait velocity according to the recommendations of the European Working Group on Sarcopenia in Older People. In both sarcopenics and non-sarcopenics elderly women, we evaluated the muscle function by knee extensors test (using an isokinetic dynamometer Byodex System 4 Pro®) at angular speeds of 60°/s and 180°/s) and also we evaluated the plasma concentrations of IL-6 and sTNFR1. Comparisons of muscle performance between groups were carried out using mixed factorial ANOVA with post hoc Bonferroni test; sTNFR1 and IL-6 variables were analyzed by applying Mann–Whitney U test.
Results:
Statistical differences were observed between groups regarding muscle power (P=0.01), total work adjusted to body weight (P=0.01) at a rate of 180°/s, and plasma levels of sTNFR1 (P=0.01).
Conclusion: Sarcopenic elder women showed lower performance of the lower limbs, especially at a higher speed, predisposing these older women to greater vulnerability in functional activities that require agility and postural stability. Plasma levels of sTNFR1 were higher for non-sarcopenics elderlies. However, due to the observational nature of the study, it was impossible to infer causality among the variables surveyed.

Keywords: sarcopenia, muscle performance, inflammatory mediators, aging

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