Comorbidity in chronic obstructive pulmonary disease. Related to disease severity?
Authors Echave-Sustaeta JM, Comeche Casanova L, G Cosio B, Soler-Cataluña JJ, Garcia-Lujan R, Ribera X
Received 28 July 2014
Accepted for publication 5 September 2014
Published 19 November 2014 Volume 2014:9(1) Pages 1307—1314
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Richard Russell
Jose M Echave-Sustaeta,1 Lorena Comeche Casanova,1 Borja G Cosio,2 Juan Jose Soler-Cataluña,3 Ricardo Garcia-Lujan,1 Xavier Ribera4
1Respiratory Department, Hospital Universitario Quirón Madrid, Madrid, Spain; 2Respiratory Department, Hospital Universitario Son Espases, Palma de Mallorca, Spain; 3Respiratory Department, Hospital Arnau de Vilanova, Valencia, Spain; 4Medical Deparment, Boehringer Ingelheim, Barcelona, Spain
Background and objective: Several diseases commonly co-exist with chronic obstructive pulmonary disease (COPD), especially in elderly patients. This study aimed to investigate whether there is an association between COPD severity and the frequency of comorbidities in stable COPD patients.
Patients and methods: In this multicenter, cross-sectional study, patients with spirometric diagnosis of COPD attended to by internal medicine departments throughout Spain were consecutively recruited by 225 internal medicine specialists. The severity of airflow obstruction was graded using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and data on demographics, smoking history, comorbidities, and dyspnea were collected. The Charlson comorbidity score was calculated.
Results: Eight hundred and sixty-six patients were analyzed: male 93%, mean age 69.8 (standard deviation [SD] 9.7) years and forced vital capacity in 1 second 42.1 (SD 17.7)%. Even, the mean (SD) Charlson score was 2.2 (2.2) for stage I, 2.3 (1.5) for stage II, 2.5 (1.6) for stage III, and 2.7 (1.8) for stage IV (P=0.013 between stage I and IV groups), independent predictors of Charlson score in the multivariate analysis were age, smoking history (pack-years), the hemoglobin level, and dyspnea, but not GOLD stage.
Conclusion: COPD patients attended to in internal medicine departments show high scores of comorbidity. However, GOLD stage was not an independent predictor of comorbidity.
Keywords: Charlson, comorbidity, COPD
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