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Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy

Authors Nakashima H, Nguyen T, Chiocca EA

Received 30 August 2015

Accepted for publication 15 October 2015

Published 20 November 2015 Volume 2015:4 Pages 183—191


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Faris Farassati

Hiroshi Nakashima, Tran Nguyen, Ennio Antonio Chiocca

Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA

Abstract: Histone deacetylase (HDAC) enzymes play a critical role in the epigenetic regulation of cellular functions and signaling pathways in many cancers. HDAC inhibitors (HDACi) have been validated for single use or in combination with other drugs in oncologic therapeutics. An even more novel combination therapy with HDACi is to use them with an oncolytic virus. HDACi may lead to an amplification of tumor-specific lytic effects by facilitating increased cycles of viral replication, but there may also be direct anticancer effects of the drug by itself. Here, we review the molecular mechanisms of anti-cancer effects of the combination of oncolytic viruses with HDACi.

Keywords: epigenetics, glioma, oncolytic virus, HDAC inhibitor, HSV-1, cancer

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