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Combination therapies for the management of nocturia and its comorbidities

Authors Yazici CM, Kurt O

Received 22 December 2014

Accepted for publication 16 February 2015

Published 20 April 2015 Volume 2015:7 Pages 57—63


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Jan Colli

Cenk Murat Yazici, Omer Kurt

Department of Urology, Namik Kemal University School of Medicine, Tekirdag, Turkey

Abstract: Nocturia is the most bothersome lower urinary tract symptom. It has a multifactorial etiology. It had been thought nocturia was a nonspecific symptom of lower urinary system dysfunction, but it has been determined that many diseases, related to different organ systems, might be reasons for this nonspecific symptom. Along with the importance of systemic diseases that cause nocturia, the symptom itself has adverse effects on patients' health and quality of life. There are several studies reporting a direct relationship between nocturia and depression, cognitive dysfunction, mood disturbances, falls, and fractures. For this reason, it is important to treat nocturia both to increase quality of life and to decrease related complications. Treatment opportunities have been under investigation for 20 years. Most of the studies in the literature have reported the results of single-drug medication on nocturia, which may be insufficient for a situation that has such a multifactorial etiology. In this review, we evaluated the success of different treatment combinations on nocturia.

Keywords: nocturia, combination, treatment, polyuria, lower urinary tract symptoms

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