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Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice

Authors Khan MA, Aljarbou AN, Aldebasi YH, Alorainy MS, Khan A

Received 24 April 2015

Accepted for publication 20 June 2015

Published 7 October 2015 Volume 2015:10(1) Pages 6331—6338

DOI https://doi.org/10.2147/IJN.S86467

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Zhaogang Yang

Peer reviewer comments 3

Editor who approved publication: Dr Thomas J Webster

Masood A Khan,1 Ahmed N Aljarbou,2 Yousef H Aldebasi,1 Mohammed S Alorainy,3 Arif Khan1

1College of Applied Medical Sciences, 2College of Pharmacy, 3College of Medicine, Qassim University, Buraydah, Saudi Arabia

Abstract: The present study aimed to assess the antitumor effect of glycosphingolipid-incorporated liposomes (glycosphingosomes) in combination with liposomal doxorubicin (Lip-Dox) in a mouse model of fibrosarcoma. Glycosphingosomes were prepared by incorporating glycosphingolipids isolated from Sphingomonas paucimobilis into the liposomes of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, cholesterol, and cardiolipin. Tumors were induced by administering dimethyl-α-benzanthracene, and tumor-bearing mice were treated with various formulations of Dox, including free Dox, Lip-Dox, or glycosphingosomes + Lip-Dox. Mice were observed for 90 days to monitor their survival and tumor size. Free Dox, but not Lip-Dox or a combination of glycosphingosomes and Lip-Dox, caused the substantial depletion of leukocytes and significantly increased the levels of lactate dehydrogenase and creatinine kinase in mice. Tumor-bearing mice treated with a combination of glycosphingosomes and Lip-Dox showed restricted tumor growth and increased survival when compared to those treated with free Dox or Lip-Dox. The results of the present study suggest that a combination of glycosphingosomes and Lip-Dox may prove to be very effective in the treatment of tumors.

Keywords: glycosphingolipids, NKT cells, tumors, chemotherapy

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