Back to Journals » Lung Cancer: Targets and Therapy » Volume 6

Combination chemotherapy of gemcitabine and vinorelbine for pretreated non-small- cell lung cancer: a retrospective study

Authors Minami S, Ogata Y, Yamamoto S, Komuta K

Received 31 May 2015

Accepted for publication 20 July 2015

Published 25 September 2015 Volume 2015:6 Pages 83—90


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Judit Pongracz

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Pan-Chyr Yang

Seigo Minami, Yoshitaka Ogata, Suguru Yamamoto, Kiyoshi Komuta

Department of Respiratory Medicine, Osaka Police Hospital, Osaka, Japan

Background: Advanced non-small-cell lung cancer (NSCLC) eventually progresses after first-line chemotherapy, and usually requires salvage treatment. Although neither gemcitabine nor vinorelbine is approved as a candidate drug in the second- or further-line for NSCLC, they can be alternative drugs in terms of anti-tumor effects and toxicities. Actually, in our institution, we often use a combination of these two anti-tumor drugs in our daily practice.
Methods: We retrospectively reviewed 85 patients with advanced NSCLC who had received combination chemotherapy of gemcitabine and vinorelbine after a platinum-based regimen from June 2007 to June 2014 in Osaka Police Hospital, and performed Cox proportional hazard analyses in order to detect predictive factors for progression-free survival (PFS).
Results: Patient characteristics included a mean age of 65.5 years, 56 males, 54 adenocarcinoma, 53 European Clinical Oncology Group performance status 0–1. Thirteen and 35 patients received the study treatment as the second- and third-line treatment, respectively. The overall response rate, disease control rate, PFS, and overall survival were 4.7% (95% confidence interval 1.3%–11.6%), 30.6% (21.0%–41.5%), 2.1 months (1.7–2.8 months), and 6.9 months (5.0–11.0 months). Twenty-one and six patients experienced grade 4 neutropenia and febrile neutropenia, respectively. European Clinical Oncology Group performance status 0–1 was detected as a factor predicting longer PFS by univariate (hazard ratio, 1.63; 95% confidence interval, 1.28–2.08; P<0.001) and multivariate (1.65, 1.27–2.14, P<0.001) analyses.
Conclusion: This combination was ineffective and harmful to pretreated patients with NSCLC. We do not recommend this regimen as a later-line treatment option.

Keywords: gemcitabine, vinorelbine, non-small cell lung cancer, performance status, retrospective study, combination chemotherapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Outcomes and prognostic factors of chemotherapy for patients with locally advanced or metastatic pulmonary squamous cell carcinoma

Minami S, Ogata Y, Ihara S, Yamamoto S, Komuta K

Lung Cancer: Targets and Therapy 2016, 7:99-110

Published Date: 24 August 2016

Retrospective analysis of outcomes and prognostic factors of chemotherapy for small-cell lung cancer

Minami S, Ogata Y, Ihara S, Yamamoto S, Komuta K

Lung Cancer: Targets and Therapy 2016, 7:35-44

Published Date: 5 April 2016

Influence of indacaterol on daily physical activity in patients with untreated chronic obstructive pulmonary disease

Nishijima Y, Minami S, Yamamoto S, Ogata Y, Koba T, Futami S, Komuta K

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:439-444

Published Date: 27 February 2015

Readers of this article also read:

First-line treatment of advanced ALK-positive non-small-cell lung cancer

Gandhi S, Chen H, Zhao Y, Dy GK

Lung Cancer: Targets and Therapy 2015, 6:71-82

Published Date: 18 September 2015

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

AXL receptor tyrosine kinase as a therapeutic target in NSCLC

Okimoto RA, Bivona TG

Lung Cancer: Targets and Therapy 2015, 6:27-34

Published Date: 30 April 2015

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010