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Color light-emitting diode reflection topography: validation of keratometric repeatability in a large sample of wide cylindrical-range corneas

Authors Kanellopoulos AJ, Asimellis G

Received 24 May 2014

Accepted for publication 31 July 2014

Published 5 February 2015 Volume 2015:9 Pages 245—252

DOI https://doi.org/10.2147/OPTH.S68371

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Anastasios John Kanellopoulos,1,2 George Asimellis1

1LaserVision.gr Clinical and Research Eye Institute, Athens, Greece; 2New York University Medical School, New York, NY, USA

Purpose: To investigate repeatability of steep and flat keratometry measurements, as well as astigmatism axis in cohorts with normal range and regular astigmatic such as: eyes following laser-assisted in situ keratomileusis (LASIK) and normal population, as well as cohorts of high and irregular astigmatism such as keratoconic eyes, and keratoconic eyes following corneal collagen cross-linking, employing a novel corneal reflection topography device.
Methods: Steep and flat keratometry and astigmatism axis measurement repeatability was investigated employing a novel multicolored-spot reflection topographer (Cassini) in four study groups, namely a post myopic LASIK-treated Group A, a keratoconus Group B, a post-CXL keratoconus Group C, and a control Group D of routine healthy patients. Three separate, maps were obtained employing the Cassini, enabling investigation of the intra-individual repeatability by standard deviation. Additionally we investigated in all groups,the Klyce surface irregularity indices for keratoconus, the SAI (surface asymmetry index) and the SRI (surface regularity index).
Results: Flat keratometry repeatability was 0.74±0.89 (0.03 to 5.26) diopters (D) in the LASIK Group A, 0.88±1.45 (range minimum to maximum, 0.00 to 7.84) D in the keratoconic Group B, and 0.71±0.94 (0.02 to 6.23) D in the cross-linked Group C. The control Group D had flat keratometry repeatability 0.36±0.46 (0.00 to 2.71) D. Steep keratometry repeatability was 0.64±0.82 (0.01 to 4.81) D in the LASIK Group A, 0.89±1.22 (0.02 to 7.85) D in the keratoconic Group B, and 0.93±1.12 (0.04 to 5.93) D in the cross-linked Group C. The control Group D had steep keratometry repeatability 0.41±0.50 (0.00 to 3.51) D. Axis repeatability was 3.45±1.62° (0.38 to 7.78°) for the LASIK Group A, 4.12±3.17° (0.02 to 12.13°) for the keratoconic Group B, and 3.20±1.99° (0.17 to 8.61°) for the cross-linked Group C. The control Group D had axis repeatability 2.16±1.39° (0.05 to 5.86°). The SAI index measurement repeatability was 0.33±0.40 (0.01 to 2.31) in the post-LASIK Group A, 0.39±0.75 (0.00 to 7.15) in the keratoconic Group B,
and 0.43±0.56 (0.05 to 3.50) in the keratoconus post-CXL Group C. The control group had SAI measurement repeatability of 0.26±0.30 (0.00 to 2.39). The SRI index repeatability was 0.22±0.17 (0.01 to 0.96) for post-LASIK Group A, 0.20±0.18 (0.00 to 1.07) in keratoconic Group B, and 0.13±0.09 (0.00 to 0.45) in the keratoconus post-CXL Group C. The control Group D had SRI measurement repeatability of 0.23±0.16 (0.00 to 0.75).
Conclusion: This novel corneal topography device appears to offer very high specificity in estimating corneal keratometry and specific corneal irregularity indices, even in topographically challenging corneas such as LASIK treated, keratoconic, and cross-linked.

Keywords: LED topography, point-source topography, VU topographer, axis of astigmatism, Cassini topographer, steep meridian, surface regularity index, surface asymmetry index, form factor

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