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Coincidence of an anterior cerebral artery aneurysm and a glioblastoma: case report and review of literature

Authors Nguyen H, Doan N, Gelsomino M, Shabani S, Mueller W, Zaidat O

Received 28 July 2015

Accepted for publication 19 August 2015

Published 25 November 2015 Volume 2015:8 Pages 295—299

DOI https://doi.org/10.2147/IMCRJ.S93271

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Ronald Prineas


Ha Son Nguyen,1 Ninh Doan,1 Michael Gelsomino,1 Saman Shabani,1 Wade Mueller,1 Osama O Zaidat2

1Department of Neurosurgery, 2Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA

Background: The association between glioblastoma and intracranial aneurysm is rare. Treatment guidelines do not exist, and operative mortality and morbidity are significantly high. To our knowledge, no prior cases have employed endovascular therapy for the treatment of these intratumor intracranial aneurysms followed by tumor resection.
Case presentation: A 74-year-old male, history of a left A2 aneurysm, presented after a motor vehicle accident at low speeds. Imaging was concerning for a possible traumatic brain contusion, an aneurysmal hemorrhage given history of left A2 aneurysm, or a hemorrhage from an underlying tumor given profound edema. The patient was discussed at the brain tumor board, where the plan was to address the aneurysm followed by resection of the mass versus close monitoring with subsequent imaging. The high risk of rehemorrhage, given the real possibility of an aneurysmal hemorrhage, motivated prompt treatment of the aneurysm. The patient was taken to the angiography suite; an anterosuperiorly projecting azygous A2 aneurysm, measuring 4.5 mm × 5.5 mm with a neck width at 3.5 mm and a small daughter sac, was completely obliterated with primary coiling. The following day, he underwent a left craniotomy along a forehead skin crease for mass excision. Final pathology revealed glioblastoma. The patient recovered well from both procedures, with a baseline neurological exam. The patient subsequently underwent hypofractionated radiation and temodar.
Conclusion: To our knowledge, no prior cases have employed endovascular therapy for the treatment of these intracranial aneurysms. We emphasize that efforts to introduce less invasive elements may improve the overall outcomes in this rare patient population.

Keywords: intracranial aneurysm, glioblastoma, traumatic brain injury

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