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Cognitive dysfunction in major depression and Alzheimer's disease is associated with hippocampus–prefrontal cortex dysconnectivity

Authors Sampath D, Sathyanesan M, Newton SS

Received 4 March 2017

Accepted for publication 11 May 2017

Published 12 June 2017 Volume 2017:13 Pages 1509—1519

DOI https://doi.org/10.2147/NDT.S136122

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Dayalan Sampath,1 Monica Sathyanesan,1,2 Samuel S Newton1,2

1Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, 2Sioux Falls VA Healthcare System, Sioux Falls, SD, USA

Abstract: Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer’s disease and depression.

Keywords: hippocampus, prefrontal cortex, cognition, depression, Alzheimer’s disease

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