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Cognitive deficits in Parkinson’s disease: current perspectives

Authors Cosgrove J, Alty JE

Received 27 October 2017

Accepted for publication 14 November 2017

Published 9 January 2018 Volume 2018:8 Pages 1—11

DOI https://doi.org/10.2147/JPRLS.S125064

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Peter Hedera


Jeremy Cosgrove, Jane Elizabeth Alty

Department of Neurology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

Abstract: Cognitive dysfunction is a common and significant non-motor symptom of Parkinson’s disease (PD). PD mild cognitive impairment (PD-MCI) is evident in approximately one-quarter of patients at the time of PD diagnosis, and half of PD patients have progressed to PD dementia (PDD) after 10 years. The transition to PDD from PD-MCI is not linear and may depend on the facets of cognition affected. Despite increased understanding of pathological, neurotransmitter and genetic drivers, there are no proven pharmacological treatments for PD-MCI and those licensed for PDD are of modest benefit only. Biomarkers to predict those most at risk of developing PDD are under investigation and are likely to be essential so that early and individualized treatment can be provided.

Keywords: Parkinson’s disease, mild cognitive impairment, dementia

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