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Coffee consumption and risk of hepatocellular carcinoma: a meta-analysis of eleven epidemiological studies

Authors Bai K, Cai Q, Jiang Y, Lv L

Received 1 April 2016

Accepted for publication 12 May 2016

Published 19 July 2016 Volume 2016:9 Pages 4369—4375

DOI https://doi.org/10.2147/OTT.S109656

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Chang Liu

Peer reviewer comments 2

Editor who approved publication: Professor Jianmin Xu


Kai Bai,* Qiucheng Cai,* Yi Jiang, Lizhi Lv

Department of Hepatobiliary Surgery, Fuzong Clinical College, Fujian Medical University, Fuzhou, People’s Republic of China

*These authors contributed equally to this work

Abstract: Growing evidence has shown that coffee consumption is inversely related with the risk of hepatocellular carcinoma. It is suggested that caffeine maintains strong antioxidative activity. With this property, coffee intake may lead to the inhibition of cell proliferation of liver cancer cells; also, some compounds contained in coffee can reduce the genotoxicity of aflatoxin B1 in vitro and lower the damage caused by some carcinogens. A computerized search was performed in PubMed to identify relevant articles published before August 2015. Eleven relevant studies were included with a total of 2,795 cases and 340,749 control subjects. According to the meta-analysis we performed, the pooled odds ratio (OR) from all included studies was 0.49 (95% confidence interval [CI] =0.46–0.52). The subgroup analysis indicated that the pooled ORs for Asian studies and other populations were 0.27 (95% CI =0.23–0.31) and 0.82 (95% CI =0.77–0.87), respectively. The overall pooled OR for high consumption was decreased to 0.21 (95% CI =0.18–0.25) and significance was observed. Among other populations, the pooled OR of subjects with high coffee consumption was 0.65 (95% CI =0.56–0.73) compared to the nondrinker. The corresponding OR of five Asian studies was 0.13 (95% CI =0.09–0.17). The findings from this meta-analysis further confirmed the inverse association between the coffee consumption and hepatocellular carcinoma risk with quantitative evidence. The protective effect can be detected among healthy population and patients with chronic liver diseases, and the consumption can also prevent the development of liver cirrhosis.

Keywords: hepatocarcinogenesis, meta-analysis, coffee, antioxidant

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