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Co-Existence of mcr-1 and blaNDM-5 in an Escherichia coli Strain Isolated from the Pharmaceutical Industry, WWTP

Authors Han H, Liu W, Cui X, Cheng X, Jiang X

Received 7 January 2020

Accepted for publication 8 March 2020

Published 16 March 2020 Volume 2020:13 Pages 851—854

DOI https://doi.org/10.2147/IDR.S245047

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Eric Nulens


Huiming Han, 1, 2 Wenhong Liu, 3 Xinjie Cui, 3 Xu Cheng, 1, 2 Xiawei Jiang 3

1Medical College, Beihua University, Jilin, People’s Republic of China; 2The Center for Infection and Immunity, Beihua University, Jilin, People’s Republic of China; 3College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China

Correspondence: Xiawei Jiang
College of Basic Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou 310053, Zhejiang, People’s Republic of China
Tel/Fax +86-571-86613613
Email xiaweijiang@zcmu.edu.cn

Abstract: The emergence of the plasmid-borne colistin-resistant gene (mcr-1) poses a great threat to human health. What is worse, the recent observations of the co-existence of mcr-1 with other antimicrobial resistance genes in some bacteria cause further concern. Here, we present the first report of a wild Escherichia coli strain that co-carries an mcr-1 encoding phage-like IncY plasmid (pR15_MCR-1) and a blaNDM-5 encoding IncX3 plasmid (pR15_NDM-5) from a pharmaceutical industry, wastewater treatment plant, in China. This study highlights the spreading of E. coli carrying both mcr-1 and blaNDM-5 genes in the pharmaceutical industry.
Importance: Escherichia coli strains that carry both mcr-1 and blaNDM-5 genes are of great health concern and are already found in humans and animals worldwide, yet there is a paucity of observations of this resistant strain in the environment. Here we present the first isolation of an E. coli strain (R15) that co-carries mcr-1 and blaNDM-5 genes from a wastewater treatment plant in China. Whole-genome sequencing indicated that R15 harbored two plasmids, pR15_MCR-1 and pR15_NDM-5, that carry mcr-1 and blaNDM-5, respectively. The observation of this wild-derived E. coli strain that carries mcr-1 and blaNDM-5 genes simultaneously calls for the urgency to improve monitoring and reducing its further spreading.

Keywords: mcr-1, blaNDM-5, wastewater treatment plant, Escherichia coli

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