Back to Browse Journals » Patient Preference and Adherence » Volume 2

Clopidogrel-taking behavior by drug-eluting stent patients: Discontinuers versus continuers

Authors Carole Decker, Linda Garavalia, Brian Garavalia, John A Spertus

Published Date June 2008 Volume 2008:2 Pages 167—175

DOI http://dx.doi.org/10.2147/PPA.S3443

Published 3 June 2008

Carole Decker1, Linda Garavalia2, Brian Garavalia1, John A Spertus1

1Mid America Heart Institute, Saint Luke’s Hospital, Kansas City, MO, USA; 2Department of Psychology, University of Missouri, Kansas City, MO, USA

Background: Each day, patients make choices whether or not to take their prescribed medications. Previous research has shown that 1 in 7 myocardial infarction (MI) patients discontinued thienopyridines within 1 month of receiving a drug-eluting stent (DES) with serious consequences. This qualitative research study explored in depth the clopidogrel-taking behavior among DES-treated patients who quit taking clopidogrel 1 month after treatment and those who continued therapy.

Methods: Sequential patients from a prospective MI registry who reported discontinuing clopidogrel within 30 days of DES treatment (N = 11) were matched with continuers (N = 11). Both groups underwent detailed qualitative phone interviews. Coding and thematic representation using directed qualitative content analysis by 3 PhD researchers was done.

Results: Patients were 41–77 years old and the majority was Caucasian and male. Multiple barriers were described by discontinuers that were not reported by continuers. The most frequently cited barrier was misunderstanding the intended duration of treatment. Discontinuers also described system weaknesses that contributed to early discontinuance such as gaps in the transition to primary care.

Conclusions: While premature discontinuation of a prescribed therapy is viewed by clinicians as a willful disregard for medical advice, early stopping of clopidogrel is influenced greatly by processes of care and system issues.

Keywords: medication discontinuance, drug-eluting stent post-care, myocardial infarction

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other article by this author:

Exploring barriers to optimal anticoagulation for atrial fibrillation: interviews with clinicians

Decker C, Garavalia L, Garavalia B, Simon T, Loeb M, Spertus J, Daniel WC

Journal of Multidisciplinary Healthcare 2012, 5:129-135

Published Date: 13 June 2012

Readers of this article also read:

Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging

Li T, Shen X, Chen Y, Zhang C, Yan J, Yang H, Wu C, Zeng H, Liu Y

International Journal of Nanomedicine 2015, 10:4279-4291

Published Date: 2 July 2015

Enzalutamide for the treatment of metastatic castration-resistant prostate cancer

Rodriguez-Vida A, Galazi M, Rudman S, Chowdhury S, Sternberg CN

Drug Design, Development and Therapy 2015, 9:3325-3339

Published Date: 29 June 2015

Cytotoxicity of graphene oxide and graphene oxide loaded with doxorubicin on human multiple myeloma cells

Wu S, Zhao X, Cui Z, Zhao C, Wang Y, Du L, Li Y

International Journal of Nanomedicine 2014, 9:1413-1421

Published Date: 14 March 2014

Decreased functional capacity and muscle strength in elderly women with metabolic syndrome

Vieira DCL, Tibana RA, Tajra V, da Cunha Nascimento D, Farias DL, Oliveira Silva A, Teixeira TG, Fonseca RMC, de Oliveira RJ, dos Santos Mendes FA, Rodrigues Martins W, Funghetto SS, Karnikowski MGO, Navalta JW, Prestes J

Clinical Interventions in Aging 2013, 8:1377-1386

Published Date: 9 October 2013

Angiopoietin-1-expressing adipose stem cells genetically modified with baculovirus nanocomplex: investigation in rat heart with acute infarction

Paul A, Nayan M, Khan AA, Shum-Tim D, Prakash S

International Journal of Nanomedicine 2012, 7:663-682

Published Date: 8 February 2012

Effect of surfactant and surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters

Mahdi ES, Sakeena MH, Abdulkarim MF, Abdullah GZ, Sattar MA, Noor AM

Drug Design, Development and Therapy 2011, 5:311-323

Published Date: 1 June 2011

Effectiveness of simple balancing training program in elderly patients with history of frequent falls

Kuptniratsaikul V, Praditsuwan R, Assantachai P, Ploypetch T, Udompunturak S, Pooliam J

Clinical Interventions in Aging 2011, 6:111-117

Published Date: 6 May 2011

Visualization of gold and platinum nanoparticles interacting with Salmonella Enteritidis and Listeria monocytogenes

Ewa Sawosz, André Chwalibog, Jacek Szeliga, et al.

International Journal of Nanomedicine 2010, 5:631-637

Published Date: 30 August 2010

Aerosol delivery by an ultrasonic nebulizer during different mechanical ventilation settings in a lung model – a pilot study

Michael Winterhalter, Michael Bund, Nawid Khaladj, Christian Hagl, Andre Simon, et al

Drug Design, Development and Therapy 2008, 2:1-7

Published Date: 8 January 2008