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Clinicopathological and prognostic significance of Ki-67 immunohistochemical expression in gastric cancer: a systematic review and meta-analysis

Authors Liu G, Xiong DS, Zeng JJ, Chen BR, Huang ZJ

Received 3 June 2017

Accepted for publication 1 August 2017

Published 1 September 2017 Volume 2017:10 Pages 4321—4328

DOI https://doi.org/10.2147/OTT.S143089

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Carlos Vigil Gonzales

Gang Liu,1,* Disheng Xiong,1,2,* Junjie Zeng,1 Borong Chen,1 Zhengjie Huang1,2

1Department of Gastrointestinal Surgery, Xiamen Cancer Hospital of the First Affiliated Hospital of Xiamen University, Xiamen, 2Department of Gastrointestinal Surgery, The First Clinical Medical College of Fujian Medical University, Fuzhou, People’s Republic of China

*These authors contributed equally to this work

Abstract: The prognostic significance of Ki-67 in patients with gastric cancer (GC) remains controversial. The aim of our meta-analysis is to evaluate its association with clinicopathological characteristics and prognostic value in patients with GC. PubMed, EMBASE, and Web of Science were systematically searched up to May 2017. Twenty-two studies including 3,825 patients with GC were analyzed. The meta-analysis indicated that the incidence difference of Ki-67 expression in GC patients was significant when comparing the older group to younger group (odds ratio [OR] =1.44, 95% confidence interval [CI] 1.19, 1.75), lymph node positive group to negative group (OR =1.49, 95% CI 1.20, 1.84), the large size tumor group to the small size tumor group (OR =1.27, 95% CI 1.24, 1.68) and the TNM stage III+IV group to TNM stage I+II group (OR =2.28, 95% CI 1.66, 3.12). However, no statistical differences existed in gender. The detection of Ki-67 significantly correlated with the overall survival of patients (hazard ratio =1.51, 95% CI 1.31, 1.72). Our study suggested that Ki-67 overexpression was associated with poor prognosis in GC patients. Ki-67 positive rates may be associated with age, lymph node metastasis, tumor size, and TNM staging system in GC patients.

Keywords: Ki-67, gastric cancer, meta-analysis, prognostic

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