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Clinical utility of landiolol for use in coronary CT angiography

Authors Tomizawa N, Hayakawa Y, Inoh S, Nojo T, Nakamura S

Received 12 September 2015

Accepted for publication 21 October 2015

Published 23 November 2015 Volume 2015:6 Pages 145—152


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Richard Kones

Nobuo Tomizawa,1 Yayoi Hayakawa,1 Shinichi Inoh,1 Takeshi Nojo,1 Sunao Nakamura2

1Department of Radiology, 2Department of Cardiology, New Tokyo Hospital, Matsudo, Chiba, Japan

Abstract: Although remarkable advancement in computed tomography (CT) has been achieved, heart rate control is important to maintain an optimal image quality in coronary CT angiography. Oral or intravenous β-blockers are used as premedication for this purpose. Landiolol was developed as a β-blocker with very high cardioselectivity (β1/β2 =255) and short half-life (4 minutes). In this review, we report the pharmacological features and usage of landiolol and also its effects on heart rate and image quality in coronary CT angiography. In addition, we discuss the safety of landiolol.

Keywords: coronary computed tomography angiography, heart rate, image quality

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