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Clinical utility of ixekizumab in the treatment of moderate-to-severe plaque psoriasis

Authors Sekhon S, Jeon C, Nakamura M, Yan D, Afifi L, Bhutani T, Levin E

Received 1 August 2017

Accepted for publication 5 October 2017

Published 16 November 2017 Volume 2017:7 Pages 65—72

DOI https://doi.org/10.2147/PTT.S129792

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Uwe Wollina


Sahil Sekhon, Caleb Jeon, Mio Nakamura, Di Yan, Ladan Afifi, Tina Bhutani, Ethan Levin

Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA

Abstract: Psoriasis vulgaris is a chronic, immune-mediated systemic disease that affects ~7.5 million people in the US. It can be treated with many therapies, often in combination, which include topicals, phototherapy, oral systemics, and biologics. Biologic agents target specific components of the immune system involved in the pathogenesis of psoriasis including TNF-alpha, IL-12, IL-17, and IL-23. The biologic ixekizumab, approved for the treatment of moderate–severe plaque psoriasis in the US, targets IL-17. This review describes the role of IL-17 in psoriasis, the mechanism by which ixekizumab targets this cytokine, and the clinical utility of ixekizumab.

Keywords:
ixekizumab, biologics, psoriasis, IL-17, anti-IL-17
 

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