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Clinical utility of gadobenate dimeglumine in contrast-enhanced MRI of the breast: a review

Authors Luciani ML, Telesca M, Kirchin M, Pediconi F

Received 1 May 2015

Accepted for publication 9 September 2015

Published 25 November 2015 Volume 2015:5 Pages 33—40

DOI https://doi.org/10.2147/RRNM.S60511

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6

Editor who approved publication: Professor Chyng-Yann Shiue


Maria Laura Luciani,1 Marianna Telesca,1 Miles A Kirchin,2 Federica Pediconi1

1Department of Radiological Sciences, Oncology and Anatomic Pathology, Sapienza University of Rome, Rome, Italy; 2Global Medical & Regulatory Affairs, Bracco Imaging SpA, Milan, Italy

Abstract: Breast magnetic resonance imaging (MRI) is considered the technique with the highest sensitivity for breast cancer detection. Gadobenate dimeglumine is a gadolinium-based contrast agent (GBCA) that is specifically approved in Europe for breast MRI and which has the highest r1 relaxivity among all GBCAs for this indication. In order to improve the diagnostic performance of breast MRI, several intra-individual crossover studies have evaluated gadobenate dimeglumine as a possible GBCA for this application. This review focuses on the role and advantages of gadobenate dimeglumine as a contrast agent for breast MRI by describing the unique properties of this agent and by summarizing published studies.

Keywords: magnetic resonance, breast imaging, oncology, breast, tumor, women's imaging

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