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Clinical utility of apixaban in the prevention and treatment of venous thromboembolism: current evidence

Authors Zalpour A, Oo TH

Received 28 July 2014

Accepted for publication 19 August 2014

Published 5 November 2014 Volume 2014:8 Pages 2181—2191

DOI https://doi.org/10.2147/DDDT.S51006

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Shu-Feng Zhou

Ali Zalpour,1 Thein Hlaing Oo2

1Division of Pharmacy – Clinical Programs, 2Section of Thrombosis and Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Abstract: Anticoagulation with heparin and vitamin K antagonist has been the mainstay of prevention and treatment of venous thromboembolism (VTE) for many years. In recent years, novel oral anticoagulants such as dabigatran etexilate (a direct thrombin inhibitor) and rivaroxaban, apixaban, and edoxaban (a direct factor Xa inhibitor) have emerged for the prevention and treatment of VTE. Novel oral anticoagulants have been shown to be noninferior to vitamin K antagonist or heparin in the prevention and treatment of VTE. This review specifically examines the role of apixaban in the prevention and treatment of VTE based on the available literature. The management of apixaban in the perioperative setting is also explored because some patients on apixaban may require surgical intervention. Finally, we discuss the management of apixaban-induced major bleeding complications, the relevance of drug–drug interactions, and patient education.

Keywords: new oral anticoagulants, apixaban, venous thromboembolism, thromboprophylaxis

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