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Clinical utility and patient adherence with ebastine for allergic rhinitis

Authors Ciprandi G

Published 14 October 2010 Volume 2010:4 Pages 389—395

DOI https://doi.org/10.2147/PPA.S8186

Review by Single-blind

Peer reviewer comments 2


Giorgio Ciprandi

Department of Internal Medicine, San Martino Hospital, Genoa, Italy

Abstract: Allergic rhinitis (AR) is a high prevalence disease, affecting 10%–20% of the general population. AR is sustained by an IgE-mediated reaction, and by a complex inflammatory network of cells, mediators, and cytokines, becoming chronic when exposure to allergen persists. A Th2-biased immune response is the basis for the allergic inflammation. Histamine plays a relevant role in symptom occurrence. Therefore, antihistamine use represents a cornerstone in AR management. Ebastine, a novel antihistamine, is effective overall in controlling symptoms, and its safety profile is good. Recently, a new formulation has been developed, ie, a fast-dissolving tablet. Several studies have demonstrated its favorable characteristics. In conclusion, ebastine is an effective and well tolerated antihistamine that may be prescribed for the treatment of AR. The fast-dissolving tablet formulation provides a new option which may be particularly convenient for the patient.

Keywords: allergic rhinitis, histamine, antihistamines, ebastine, tablets

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