Back to Browse Journals » Infection and Drug Resistance » Volume 5

Clinical update on linezolid in the treatment of Gram-positive bacterial infections

Authors Ager S, Gould K

Received 13 April 2012

Accepted for publication 20 April 2012

Published 25 June 2012 Volume 2012:5 Pages 87—102


Review by Single-blind

Peer reviewer comments 2

Sally Ager, Kate Gould

Department of Microbiology, Newcastle upon Tyne Hospitals Trust, Freeman Hospital, High Heaton, Newcastle upon Tyne, UK

Abstract: Gram-positive pathogens are a significant cause of morbidity and mortality in both community and health care settings. Glycopeptides have traditionally been the antibiotics of choice for multiresistant Gram-positive pathogens but there are problems with their use, including the emergence of glycopeptide-resistant strains, tissue penetration, and achieving and monitoring adequate serum levels. Newer antibiotics such as linezolid, a synthetic oxazolidinone, are available for the treatment of resistant Gram-positive bacteria. Linezolid is active against a wide range of Gram-positive bacteria and has been generally available for the treatment of Gram-positive infections since 2000. There are potential problems with linezolid use, including its bacteriostatic action and the relatively high incidence of reported adverse effects, particularly with long-term use. Long-term use may also be complicated by the development of resistance. However, linezolid has been shown to be clinically useful in the treatment of several serious infections where traditionally bacteriocidal agents have been required and many of its adverse effects are reversible on cessation. It has also been shown to be a cost-effective treatment option in several studies, with its high oral bioavailability allowing an early change from intravenous to oral formulations with consequent earlier patient discharge and lower inpatient costs.

Keywords: linezolid, oxazolidinone, multi-resistant, gram-positive, MRSA, VRE, cost-benefit

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] View Full Text [HTML] 


Readers of this article also read:

Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique

Anarjan N, Jafarizadeh-Malmiri H, Nehdi IA, Sbihi HM, Al-Resayes SI, Tan CP

International Journal of Nanomedicine 2015, 10:1109-1118

Published Date: 4 February 2015

A scalable fabrication process of polymer microneedles

Yang S, Feng Y, Zhang L, Chen N, Yuan W, Jin T

International Journal of Nanomedicine 2012, 7:1415-1422

Published Date: 12 March 2012

McArdle disease: a case report and review

Leite A, Oliveira N, Rocha M

International Medical Case Reports Journal 2012, 5:1-4

Published Date: 20 January 2012


Krikeli M, Ekonomopoulou MT, Tzitzikas I, Goutzioulis A, Mystakidou K, Pistevou-Gompaki K

Cancer Management and Research 2011, 3:319-320

Published Date: 5 December 2011

Central retinal artery occlusion resembling Purtscher-like retinopathy

Kurimoto T, Okamoto N, Oku H, Kanbara Y, Etomi T, Tonari M, Ikeda T

Clinical Ophthalmology 2011, 5:1083-1088

Published Date: 4 August 2011

Update on the management of inflammatory bowel disease: specific role of adalimumab

Guidi L, Pugliese D, Armuzzi A

Clinical and Experimental Gastroenterology 2011, 4:163-172

Published Date: 15 July 2011

Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo

Bao-an Chen, Bin-bin Lai, Jian Cheng, et al

International Journal of Nanomedicine 2009, 4:201-208

Published Date: 23 September 2009

Pegaptanib sodium treatment in neovascular age-related macular degeneration: clinical experience in Germany

Nikolaus Feucht, Huebner Matthias, Chris P Lohmann, Mathias Maier

Clinical Ophthalmology 2008, 2:253-259

Published Date: 6 June 2008