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Clinical presentation, treatment, and prognosis of periocular and orbital amyloidosis in a university-based referral center

Authors Aryasit O, Preechawai P, Kayasut K

Received 19 December 2012

Accepted for publication 20 February 2013

Published 30 April 2013 Volume 2013:7 Pages 801—805


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Orapan Aryasit, Passorn Preechawai, Kanita Kayasut

Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand

Objective: The purpose was to present the demographic data, clinical presentation, and treatment options, and to evaluate prognosis, for periocular and orbital amyloidosis in patients at the Songklanagarind Hospital, Thailand.
Method: This was a retrospective study that reviewed the clinical records of six patients who were diagnosed with periocular and orbital amyloidosis between January 1, 2002 and December 31, 2011.
Results: The series included six patients (five female and one male). The mean age was 39.7 years (range 15–79 years). There were five cases of unilateral lesion and one case of bilateral lesion. The most common symptom was a mass lesion (83.3%), followed by irritation (66.7%), bloody tears (16.7%), epiphora (16.7%), eye pain (16.7%), and ptosis (16.7%). Five cases had periocular involvement and one case had orbital involvement. Five cases were investigated to rule out systemic amyloidosis, and no systemic involvement was found in these cases. The median duration of symptoms was 6 months, but the mean was 31 months. The main treatment option was surgical excision. The mean follow-up time was 41 months. There was disease progression in 20% of cases after definitive treatment.
Conclusion: Periocular and orbital amyloidosis presented with a variety of symptoms, depending on the location of the disease. A mass lesion was the most common symptom. The intent of the treatment modalities was to spare function.

Keywords: primary localized amyloidosis, eyelid, conjunctiva

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