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Clinical potential of aclidinium bromide in chronic obstructive pulmonary disease

Authors Zhong J, Roth M

Received 16 October 2013

Accepted for publication 17 January 2014

Published 13 June 2014 Volume 2014:10 Pages 449—453

DOI https://doi.org/10.2147/TCRM.S39710

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Jun Zhong, Michael Roth

Pneumology and Pulmonary Cell Research, Department of Biomedicine and Internal Medicine, University Hospital Basel, Basel, Switzerland

Abstract: Chronic obstructive pulmonary disease (COPD) is increasing worldwide and is predicted to become the third most frequent cause of death by 2030. Muscarinic receptor antagonists, alone or in combination with long-acting ß2-agonists, are frequently used for COPD therapy. Aclidinium bromide is a novel muscarinic receptor antagonist, and clinical studies indicate that its metabolism is more rapid than that of other muscarinic receptor inhibitors, so systemic side effects are expected to occur less frequently. Aclidinium bromide is well tolerated, and when compared with other muscarinic receptor antagonists, the drug achieves better control of lung function, especially night-time symptoms in COPD patients. This review summarizes the safety profile and side effects reported by recent clinical studies using aclidinium bromide alone.

Keywords: aclidinium, tiotropium, side effects, clinical safety

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