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Clinical, patient-related, and economic outcomes of home-based high-dose hemodialysis versus conventional in-center hemodialysis

Authors Mitsides N, Mitra S, Cornelis T

Received 8 December 2015

Accepted for publication 9 March 2016

Published 5 July 2016 Volume 2016:9 Pages 151—159

DOI https://doi.org/10.2147/IJNRD.S89411

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Yuvaram N V Reddy

Peer reviewer comments 2

Editor who approved publication: Professor Pravin Singhal


Nicos Mitsides,1,2 Sandip Mitra,1,2 Tom Cornelis3

1Department of Renal Medicine, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Center, Manchester, 2National Institute for Healthcare Research Devices for Dignity Healthcare Co-operative, Sheffield, UK; 3Department of Nephrology, Jessa Hospital, Hasselt, Belgium

Abstract: Despite technological advances in renal replacement therapy, the preservation of health and quality of life for individuals on dialysis still remains a challenge. The high morbidity and mortality in dialysis warrant further research and insight into the clinical domains of the technique and practice of this therapy. In the last 20 years, the focus of development in the field of hemodialysis (HD) has centered around adequate removal of urea and other associated toxins. High-dose HD offers an opportunity to improve mortality, morbidity, and quality of life of patients with end-stage kidney disease. However, the uptake of this modality is low, and the risk associated with the therapy is not fully understood. Recent studies have highlighted the evidence base and improved our understanding of this technique of dialysis. This article provides a review of high-dose and home HD, its clinical impact on patient outcome, and the controversies that exist.

Keywords: hemodialysis, home dialysis, high dose, outcomes

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