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Clinical outcome of incidentally discovered small renal cell carcinoma after delayed surgery

Authors Sugimoto K , Shimizu N, Takashi Oki, Nose K, Nishioka T, Adomi S, Ohzeki T, Esa A, Uemura H

Received 19 February 2013

Accepted for publication 12 April 2013

Published 24 May 2013 Volume 2013:5 Pages 85—89


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Koichi Sugimoto,1,2 Nobutaka Shimizu,1 Takashi Oki,2 Kazuhiro Nose,2 Tsukasa Nishioka,2 Shogo Adomi,3 Takayuki Ohzeki,3 Atsunobu Esa,3 Hirotsugu Uemura1

1Department of Urology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan; 2Department of Urology, Sakai Hospital Kinki University Faculty of Medicine, Sakai, Osaka, Japan; 3Department of Urology, NTT West Osaka Hospital, Osaka, Osaka, Japan

Background: This study was undertaken to investigate the growth rate and clinical outcome of patients with a small renal mass (SRM) after delayed surgery.
Methods: We reviewed the clinical records of 34 patients with SRMs 4 cm at diagnosis, who underwent delayed surgical intervention during surveillance from January 2000 to December 2011. Radiographic evaluations using computed tomography (CT) scan and magnetic resonance imaging (MRI) were performed at least every 6 months, and the tumor size was determined at least twice.
Results: The mean follow-up time was 26.6 ± 18.6 months and mean tumor doubling time was 23.4 ± 16.0 months. Histopathological analysis revealed that 32 of the 34 patients were malignant in pT1aN0M0. Only one patient showed tumor recurrence, who subsequently died due to tumor progression.
Conclusion: The growth rate of the small renal mass was slow in the majority of our patients. Delayed intervention does not have a detrimental effect on cancer-specific outcomes.

Keywords: renal cell carcinoma, small renal mass, natural history, growth rate, delayed intervention

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