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Clinical neurorestorative progresses in cerebral palsy

Authors Sharma A, Geng T, Sane H, Kulkarni P

Received 23 October 2015

Accepted for publication 4 February 2016

Published 23 February 2017 Volume 2017:5 Pages 51—57

DOI https://doi.org/10.2147/JN.S99014

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Chandler Walker

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Hari Shanker Sharma


Alok Sharma,1 Tongchao Geng,2 Hemangi Sane,3 Pooja Kulkarni3

1Department of Medical Services & Clinical Research, NeuroGen Brain and Spine Institute, Mumbai, India; 2Department of Neurology, Yuquan Hospital, Tsinghua University, Beijing, People’s Republic of China; 3Department of Research and Development, Neurogen Brain and Spine Institute, Mumbai, India

Abstract: Cerebral palsy (CP), group of permanent nonprogressive clinical disorders in children, is caused by damage to the immature brain. Conventionally available treatments for CP are mainly targeted toward management of its symptoms. With the upcoming field of neurorestorative strategies, we are now able to repair the core brain damage in CP. There are various drugs, stem cells, etc, which have been implicated to have neurorestorative properties. Autologous bone marrow stem cells, umbilical cord stem cells, neural stem cells, and olfactory ensheathing cells have shown the safety and efficacy in preliminary studies. Here, we review the different medicines and cell types that have shown beneficial effects in clinical studies. We propose that combination strategies may be the future of neurorestoration.

Keywords: stem cell therapy, bone marrow, umbilical cord, neural cells, regenerative medicine, brain

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