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Clinical issues of mucus accumulation in COPD

Authors Ramos FL, Krahnke JS, Kim V

Received 18 September 2013

Accepted for publication 2 December 2013

Published 24 January 2014 Volume 2014:9(1) Pages 139—150

DOI https://doi.org/10.2147/COPD.S38938

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Frederick L Ramos, Jason S Krahnke, Victor Kim

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA

Abstract: Airway mucus is part of the lung's native immune function that traps particulates and microorganisms, enabling their clearance from the lung by ciliary transport and cough. Mucus hypersecretion and chronic productive cough are the features of the chronic bronchitis and chronic obstructive pulmonary disease (COPD). Overproduction and hypersecretion by goblet cells and the decreased elimination of mucus are the primary mechanisms responsible for excessive mucus in chronic bronchitis. Mucus accumulation in COPD patients affects several important outcomes such as lung function, health-related quality of life, COPD exacerbations, hospitalizations, and mortality. Nonpharmacologic options for the treatment of mucus accumulation in COPD are smoking cessation and physical measures used to promote mucus clearance. Pharmacologic therapies include expectorants, mucolytics, methylxanthines, beta-adrenergic receptor agonists, anticholinergics, glucocorticoids, phosphodiesterase-4 inhibitors, antioxidants, and antibiotics.

Keywords: chronic obstructive pulmonary disease, chronic bronchitis, mucus, sputum


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