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Clinical evaluation of the role of ceftaroline in the management of community acquired bacterial pneumonia

Authors Maselli DJ, Fernandez JF, Whong CY, Echevarria K, Nambiar AM, Anzueto A, Restrepo MI

Received 2 November 2011

Accepted for publication 28 December 2011

Published 1 February 2012 Volume 2012:5 Pages 43—51

DOI https://doi.org/10.2147/IDR.S17433

Review by Single-blind

Peer reviewer comments 2

Diego J Maselli1, Juan F Fernandez1, Christine Y Whong2, Kelly Echevarria1,3, Anoop M Nambiar1,3, Antonio Anzueto1,3, Marcos I Restrepo1,3,4
1University of Texas Health Science Center, San Antonio, Texas, 2Memorial Hermann – Texas Medical Center, Houston, TX, 3South Texas Veterans Health Care System Audie l Murphy Division, San Antonio, TX, 4Veterans Evidence Research Dissemination and Implementation Center (VERDICT), San Antonio, TX, USA

Abstract: Ceftaroline fosamil (ceftaroline) was recently approved for the treatment of community-acquired pneumonia (CAP) and complicated skin infections. This newly developed cephalosporin possesses a broad spectrum of activity against gram-positive and gram-negative bacteria. Most importantly, ceftaroline demonstrates potent in vitro antimicrobial activity against multi-drug resistant Streptococcus pneumoniae and methicillin-resistant strains of Staphylococcus aureus. In two Phase III, double-blinded, randomized, prospective trials (FOCUS 1 and FOCUS 2), ceftaroline was shown to be non-inferior to ceftriaxone for the treatment of CAP in hospitalized patients. Ceftaroline exhibits low resistance rates and a safety profile similar to that of other cephalosporins. In this review, we will evaluate the pharmacological characteristics, safety, antimicrobial properties, and efficacy of ceftaroline and its applications in the treatment of CAP.

Keywords: s. pneumoniae, s. aureus, cephalosporins, pneumonia, ceftaroline, community acquired pneumonia

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