Clinical effect and safety of pulsed radiofrequency treatment for pudendal neuralgia: a prospective, randomized controlled clinical trial
Authors Fang H, Zhang J, Yang Y, Ye L, Wang X
Received 11 March 2018
Accepted for publication 27 July 2018
Published 16 October 2018 Volume 2018:11 Pages 2367—2374
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Erica Wegrzyn
Hongwei Fang,1,2,* Jinyuan Zhang,2,* Yu Yang,1,* Le Ye,2 Xiangrui Wang1
1Department of Anesthesiology and Intensive Care Unit, Dongfang Hospital, Tongji University, Shanghai, China; 2Department of Pain Management, South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
*These authors contributed equally to this work
Background: Pudendal neuralgia is an intractable pain related to the pudendal nerve. The clinical effect and safety evaluation of pudendal neuralgia were investigated by pulse radiofrequency (PRF) treatment of pudendal nerve.
Patients and methods: Eighty patients who were diagnosed with pudendal neuralgia were randomly divided into PRF group (PRF and pudendal nerve block [NB]) and NB group. After surgery, the patients were followed up to evaluate the visual analog scale (VAS) score and the Patient Health Questionnaire score on the postoperative day and at 2 weeks, 1 and 3 months. Meanwhile, the patients’ efficacy assessment and the usage of pain medication were also recorded for 3 months during follow-up. All the surgical complications were recorded.
Results: A total of 77 patients were followed up, 38 in the PRF group and 39 in the NB group. On the postoperative day, the VAS scores was significantly decreased in both groups than before (P<0.01), whereas there was no statistical difference within the two groups (P>0.05). However, the VAS score of PRF group was significantly lower than that of NB group in 2 weeks, 1 and 3 months after surgery, respectively (P<0.01). In the meanwhile, the Patient Health Questionnaire score of PRF group was also significantly lower than that of NB group (P<0.01) in 3 months after the operation. The clinical effective rate of PRF group was 92.1% in 3 months after surgery, while this rate was only 35.9% in the NB group. The postoperative analgesic usage of PRF group was superior to that of NB group (P<0.01). No severe adverse events were observed in either group.
Conclusion: Compared with the single NB treatment, pudendal nerve PRF combined with NB therapy could provide more long-lasting relief from pain symptoms of pudendal neuralgia and improve the depression symptoms in patients.
Keywords: pudendal neuralgia, pulse radiofrequency treatment, pudendal nerve block, ultrasound guidance, visual analog scale, PHQ-9
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