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Clinical development of neridronate: potential for new applications

Authors Gatti D, Rossini M, Viapiana O, Idolazzi L, Adami S

Received 31 January 2013

Accepted for publication 26 February 2013

Published 3 April 2013 Volume 2013:9 Pages 139—147

DOI https://doi.org/10.2147/TCRM.S35788

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Davide Gatti, Maurizio Rossini, Ombretta Viapiana, Luca Idolazzi, Silvano Adami

Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy

Abstract: Neridronate is an aminobisphosphonate, licensed in Italy for the treatment of osteogenesis imperfecta (OI) and Paget's disease of bone (PDB). A characteristic property of neridronate is that it can be administered both intravenously and intramuscularly, providing a useful system for administration in homecare. In this review, we discuss the latest clinical results of neridronate administration in OI and PDB, as well as in osteoporosis and other conditions. We will focus in particular on the latest evidence of the effect of neridronate on treatment of complex regional pain syndrome type I.

Keywords: bisphosphonates, osteogenesis imperfecta, osteoporosis, complex regional pain syndrome

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