Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma
Received 30 November 2018
Accepted for publication 16 February 2019
Published 23 May 2019 Volume 2019:12 Pages 4025—4031
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Takuya Aoki
Zihong Wang,1,2* Jing Tang,3* Yufan Wang,1 Shuai Sun,1 Yuling Chen,1 Yuehong Shen,1 Hong-Yu Yang1
1Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China; 2Peking University Shenzhen Hospital Clinical College, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 3Jingzhou Central Hospital, Jingzhou, Hubei, People’s Republic of China
*These authors contributed equally to this work
Background: Oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy in humans. Increasing numbers of studies suggest that circular RNAs (circRNAs) play a major role in tumorigenesis and tumor progression.
Purpose: We aimed to identify differently expressed circRNA in OSCC and adjacent normal tissue. As well as to study the correlation of circRNA expression with clinicopathological feature in patients with OSCC.
Patients and methods: Primary OSCC tissues and adjacent normal tissues from twenty-seven OSCC patients were collected. The expression level of hsa_circ_009755 were analyzed by qRT-PCR.
Results: The measurement results from qRT-PCR revealed that hsa_circ_009755 expression was low in OSCC tissue samples and cell lines, and the low expression of hsa_circ_009755 was closely related to a clinicopathological feature in patients with OSCC. Moreover, the area under the receiver operating characteristic curve was 0.782, which indicates the sensitivity and specificity of the diagnostic value.
Conclusion: Our data indicates that hsa_circ_009755 could serve as a potential biomarker for OSCC diagnosis.
Keywords: oral squamous cell carcinoma, circular RNA, biomarker, hsa_circ_009755
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